1265584-51-7Relevant articles and documents
Design and synthesis of aryl ether and sulfone hydroxamic acids as potent histone deacetylase (HDAC) inhibitors
Pabba, Chittari,Gregg, Brian T.,Kitchen, Douglas B.,Chen, Zhen Jia,Judkins, Angela
scheme or table, p. 324 - 328 (2011/02/27)
A series of novel hydroxamic acid based histone deacetylases (HDAC) inhibitors with aryl ether and aryl sulfone residues at the terminus of a substituted, unsaturated 5-carbon spacer moiety have been synthesized for the first time and evaluated. Compounds with meta- and para-substitution on the aryl ring of ether hydroxamic acids 19c, 20c, 19e, 19f and 19g are potent HDAC inhibitors with activities at low nanomolar levels.
