12656-61-0

Basic information

• Product Name: cerebrolysin
• Synonyms: cerebrolysin;FPE 1070
• CAS NO: 12656-61-0
• Molecular Weight: 0
• EINECS: 1592732-453-0
• Mol File: 12656-61-0.mol
• Article Data: 0

Chemical Properties

• Appearance: Light yellow powder
• CAS DataBase Reference: cerebrolysin(CAS DataBase Reference)
• NIST Chemistry Reference: cerebrolysin(12656-61-0)
• EPA Substance Registry System: cerebrolysin(12656-61-0)

Safety Data

• Hazardous Substances Data: 12656-61-0(Hazardous Substances Data)

Usage

Pharmacological Study

Cerebrolysin is a peptidergic drug produced from purified porcine brain proteins, with postulated neurotrophic and neuroprotective effects (Windisch et al., 1998; Rockenstein et al., 2003; Plosker and Gauthier, 2009; Gauthier et al., 2015). A small open-label trial in patients with AD and VaD (Rainer et al., 1997) showed minimal improvement in cognitive tests and clinical global impression. The main side effects were nausea and vertigo. A Cochrane review (Chen et al., 2013) of six RCTs with a total of 597 participants showed minimal MMSE and ADAS-cog improvements.

Related news

cerebrolysin (cas 12656-61-0) attenuates ethanol-induced spatial memory impairments through inhibition of hippocampal oxidative stress and apoptotic cell death in rats08/22/2019

The present study investigates the potential neuroprotective effect of cerebrolysin (CBL), a combination of neurotrophic factors, on the cognitive and biochemical alterations induced by chronic ethanol administration in rats. The animals were divided into five groups as follows: control; ethanol...detailed

Clinical StudyRole of cerebrolysin (cas 12656-61-0) in cervical spondylotic myelopathy patients: a prospective randomized study08/21/2019

Background ContextCerebrolysin is a mixture containing 85% free amino acids and 15% biologically active low–molecular weight peptides that is believed to mimic the effects of endogenous neurotrophic factors to interact with the pathologic process cascade of neurodegenerative diseases. No study ...detailed

Ameliorative effects of cerebrolysin (cas 12656-61-0) against isoproterenol-induced myocardial injury in male rats08/20/2019

AimsMyocardial injury (MI) is the principal cause of death from cardiovascular disease (CVD). The present study was conducted to investigate the ameliorative and antioxidant effects of cerebrolysin (CBL) on isoproterenol-induced MI in rats.detailed

Subchronic cerebrolysin (cas 12656-61-0) treatment alleviates cognitive impairments and dendritic arborization alterations of granular neurons in the hippocampal dentate gyrus of rats with temporal lobe epilepsy08/19/2019

Temporal lobe epilepsy (TLE) is one of the most frequent forms of focal epilepsy; patients with this condition, in addition to exhibiting complex seizures, also exhibit cognitive deficits. In the temporal lobe, the hippocampus, a structure relevant to learning and memory processes, is particular...detailed

Prospective, double blinded, comparative assessment of the pharmacological activity of cerebrolysin (cas 12656-61-0) and distinct peptide preparations for the treatment of embolic stroke08/18/2019

BackgroundOur previous work in acute ischemic stroke and TBI models focused on efficacy and pharmacological parameters of Cerebrolysin®. In this prospective, randomized, blinded, placebo-controlled study we compared efficacy of neuropeptide preparations with putative neurotrophic potential to th...detailed

Effect of cerebrolysin (cas 12656-61-0) on the cerebellum of diabetic rats: An imunohistochemical study08/17/2019

BackgroundDiabetes mellitus represents one of the disorders in the metabolism that affects all body systems including CNS. Cerebrolysin contains many neurotrophic factors, and many studies reported that it can be used treatment of many neurological disorders.detailed

Original articleCardioprotective effects of cerebrolysin (cas 12656-61-0) on the lesion severity and inflammatory factors in a rat model of isoproterenol-induced myocardial injury08/15/2019

BackgroundMyocardial injury (MI) is an important heart condition and a major cause of morbidity and mortality worldwide. The current study was designed to investigate the cardioprotective effects of cerebrolysin (CLY) on the lesion severity and inflammatory factors in male rats using isoproteren...detailed