1265789-88-5

Basic information

• Product Name: S6K-18
• Synonyms: S6K-18;2-(3-(1H-Indazol-5-yl)ureido)-5-(tert-butyl)thiophene-3-carboxylic acid
• CAS NO: 1265789-88-5
• Molecular Formula: C17H18N4O3S
• Molecular Weight: 358.42
• Mol File: 1265789-88-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator, Under inert atmosphere
• Solubility: Aqueous Base (Slightly, Heated), DMSO (Slightly)
• CAS DataBase Reference: S6K-18(CAS DataBase Reference)
• NIST Chemistry Reference: S6K-18(1265789-88-5)
• EPA Substance Registry System: S6K-18(1265789-88-5)

Safety Data

• Hazardous Substances Data: 1265789-88-5(Hazardous Substances Data)

Usage

Uses

2-(3-(1H-Indazol-5-yl)ureido)-5-(tert-butyl)thiophene-3-carboxylic Acid can be used as potent and selective thiophene urea-templated inhibitors of S6K.

Upstream product

• 2987-16-8 3,3-dimethylbutyrylaldehyde 
• 890664-87-6 6-tert-butyl-1H-thieno[2,3-d][1,3]oxazine-2,4-dione 
• 19335-11-6 1H-indazol-5-ylamine 
• 216574-71-9 2-amino-5-tert-butylthiophene-3-carboxylic acid methyl ester 

Relevant articles and documents

Potent and selective thiophene urea-templated inhibitors of S6K

S6K1 (p70 S6 kinase-1) is thought to play a critical role in the development of obesity and insulin resistance, thus making it an attractive target in developing medicines for the treatment of these disorders. We describe a novel thiophene urea class of S6K inhibitors. The lead matter for the development of these inhibitors came from mining the literature for reports of weak off-target S6K activity. These optimized inhibitors exhibit good potency and excellent selectivity for S6K over a panel of 43 kinases.