126583-37-7 Usage
Derivative of pyrazole
The compound is based on a pyrazole ring, which is a five-membered heterocyclic ring containing two nitrogen atoms.
Carboxylic acid group
The compound contains a carboxylic acid group (-COOH), which is a functional group consisting of a carbonyl group (C=O) and a hydroxyl group (-OH) bonded to the same carbon atom.
Amino group
The compound also contains an amino group (-NH2), which is a functional group consisting of a nitrogen atom bonded to two hydrogen atoms.
Pyridine ring
The compound features a pyridine ring, which is a six-membered heterocyclic ring containing one nitrogen atom in place of a carbon atom.
Potential applications in medicinal chemistry
1H-Pyrazole-4-carboxylic acid, 5-amino-1-(2-pyridinyl)-(9CI) may be used in the development of pharmaceutical drugs due to its unique structure and properties.
Biological activity
The compound may exhibit biological activity, which could make it useful in the treatment of various diseases or conditions.
Building block for synthesis
1H-Pyrazole-4-carboxylic acid, 5-amino-1-(2-pyridinyl)-(9CI) could be used as a starting material for the synthesis of other compounds with desired properties.
Further research and testing needed
To fully understand the potential uses and effects of this compound, additional research and testing are required.
Check Digit Verification of cas no
The CAS Registry Mumber 126583-37-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,6,5,8 and 3 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 126583-37:
(8*1)+(7*2)+(6*6)+(5*5)+(4*8)+(3*3)+(2*3)+(1*7)=137
137 % 10 = 7
So 126583-37-7 is a valid CAS Registry Number.
126583-37-7Relevant articles and documents
5-Amino-pyrazoles as potent and selective p38α inhibitors
Das, Jagabandhu,Moquin, Robert V.,Dyckman, Alaric J.,Li, Tianle,Pitt, Sidney,Zhang, Rosemary,Shen, Ding Ren,McIntyre, Kim W.,Gillooly, Kathleen,Doweyko, Arthur M.,Newitt, John A.,Sack, John S.,Zhang, Hongjian,Kiefer, Susan E.,Kish, Kevin,McKinnon, Murray,Barrish, Joel C.,Dodd, John H.,Schieven, Gary L.,Leftheris, Katerina
scheme or table, p. 6886 - 6889 (2011/02/22)
The synthesis and structure-activity relationships (SAR) of p38α MAP kinase inhibitors based on a 5-amino-pyrazole scaffold are described. These studies led to the identification of compound 2j as a potent and selective inhibitor of p38α MAP kinase with excellent cellular potency toward the inhibition of TNFα production. Compound 2j was highly efficacious in vivo in inhibiting TNFα production in an acute murine model of TNFα production. X-ray co-crystallography of a 5-amino-pyrazole analog 2f bound to unphosphorylated p38α is also disclosed.
