126597-52-2

Upstream product

• 129441-76-5 Acetic acid (6R,7S)-7-chloro-2-chlorocarbonyl-5,5,8-trioxo-5λ⁶-thia-1-aza-bicyclo[4.2.0]oct-2-en-3-ylmethyl ester 
• 145757-83-1 7α-chloro-3-methyl-1,1-dioxoceph-3-em-4-carboxylic acid sulfone chloride 
• 126621-87-2 3-(acetoxymethyl)-7α-chloro-Δ³-cephem-4-carboxylic acid 1,1-dioxide 
• 148115-13-3 7α-chloro-3-methyl-1,1-dioxoceph-3-em-4-carboxylic acid sulfone 

Relevant academic research and scientific papers

Cephem sulfones as inactivators of human leukocyte elastase. 5. 7α- Methoxy- and 7α-chloro-1,1-dioxocephem 4-ketones

Studies on cephem sulfones as inhibitors of human leukocyte elastase (HLE) have been extended to the new class of cephem 4-ketones. tert-Butyl and phenyl ketones were prepared from 4-carboxycephem derivatives, at either the sulfide or sulfone oxidation le

Synthesis of novel cephem-4-ketones. A new series of human leukocyte elastase inhibitors

Alkylation of cephem-4-carbonyl chlorides at the sulphide or sulphone oxidation level with Grignard reagents, stannanes and cuprates is described. Radical or ionic bromination of the 3-methylcephem-4-ketone 8, followed by displacement with heterocyclic th