Quinupristin-dalfopristin is a combination of two semi-synthetic antibacterial agents, dalfopristin and quinupristin, which belong to the class of streptogramins. They form Synercid, an injectable formulation with a ratio of 70:30, and work synergistically at the ribosomal level to inhibit protein synthesis. This combination is highly effective as an antibiotic, including against resistant strains, and is the first of its class to reach the market.
126602-89-9
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Basic information
- Product Name: Quinupristin-dalfopristin
- Synonyms: Quinupristin-dalfopristin;SYNERCID;Quinupristin-Dalfopristin Mesylate coMplex;Synercid coMplex, Dalfopristin-Quinupristin coMplex;Mixture with quinupristin
- CAS NO:126602-89-9
- Molecular Formula: C53H67N9O10S.C34H50N4O9S
- Molecular Weight: 1713.09
- EINECS: N/A
- Product Categories: N/A
- Mol File: 126602-89-9.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: °Cat760mmHg
- Flash Point: °C
- Appearance: /
- Density: g/cm3
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: Quinupristin-dalfopristin(CAS DataBase Reference)
- NIST Chemistry Reference: Quinupristin-dalfopristin(126602-89-9)
- EPA Substance Registry System: Quinupristin-dalfopristin(126602-89-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 126602-89-9(Hazardous Substances Data)
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126602-89-9 Usage
Uses
Used in Pharmaceutical Industry:Quinupristin-dalfopristin is used as an antibiotic for treating severe or life-threatening infections, particularly those caused by gram-positive bacteria such as vancomycin-resistant Enterococcus faecium (VREF) or methicillin-resistant Staphylococcus aureus (MRSA). The synergistic action of the two components at the ribosomal level makes it a promising treatment alternative for patients with these infections.
Originator
Rhone-Poulenc-Rorer (France)Check Digit Verification of cas no
The CAS Registry Mumber 126602-89-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,6,6,0 and 2 respectively; the second part has 2 digits, 8 and 9 respectively.Calculate Digit Verification of CAS Registry Number 126602-89:
(8*1)+(7*2)+(6*6)+(5*6)+(4*0)+(3*2)+(2*8)+(1*9)=119
119 % 10 = 9
So 126602-89-9 is a valid CAS Registry Number.
InChI:InChI=1/C53H67N9O10S.C34H50N4O9S/c1-6-37-50(68)61-23-11-14-38(61)51(69)59(5)40(26-32-16-18-36(19-17-32)58(3)4)52(70)62-28-35(30-73-43-29-60-24-20-33(43)21-25-60)42(64)27-39(62)47(65)57-45(34-12-8-7-9-13-34)53(71)72-31(2)44(48(66)55-37)56-49(67)46-41(63)15-10-22-54-46;1-7-37(8-2)16-17-48(44,45)28-13-15-38-31(28)34(43)47-32(22(3)4)24(6)11-12-29(41)35-14-9-10-23(5)18-25(39)19-26(40)20-30-36-27(21-46-30)33(38)42/h7-10,12-13,15-19,22,31,33,35,37-40,43-45,63H,6,11,14,20-21,23-30H2,1-5H3,(H,55,66)(H,56,67)(H,57,65);9-12,18,21-22,24-25,28,31-32,39H,7-8,13-17,19-20H2,1-6H3,(H,35,41)/b;10-9-,12-11-,23-18-/t31-,35+,37+,38+,39?,40+,43-,44+,45+;24-,25-,28-,31-,32-/m11/s1
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Quinupristin-dalfopristin
