126631-72-9

Upstream product

• 154077-24-4 3-Bromo-2-(3,4-dimethoxy-phenyl)-pyrrolidine-1-carboxylic acid methyl ester 
• 154077-25-5 2-(3,4-Dimethoxy-phenyl)-3-iodo-pyrrolidine-1-carboxylic acid methyl ester 
• 91-16-7 1,2-dimethoxybenzene 
• 126631-71-8 3-(3,4-Dimethoxy-phenyl)-pyrrolidine-1,2-dicarboxylic acid 1-methyl ester 
• 126651-52-3 3-(3,4-Dimethoxy-phenyl)-pyrrolidine-1,2,2-tricarboxylic acid trimethyl ester 

Downstream Products

• 20802-18-0 4-(3,4-dimethoxy-phenyl)-1-methyl-2,3-dihydro-pyrrole 
• 6023-73-0 mesembrine 

Relevant academic research and scientific papers

A Convenient Route to β-Aryl-substituted Cyclic Enamines as Key Synthetic Intermediates of Sceletium and Amaryllidaceae Alkaloids

Aryl groups were introduced into the position β to the nitrogen atom of cyclic amines by carrying out the anodic α-methoxylation of cyclic amine derivatives, the elimination of methanol from the oxidized products, the halomethoxylation of the resulting α,β-unsaturated cyclic amine derivatives, the replacement of the α-methoxy group with an aryl group, and the silver ion-promoted migration of the α-aryl group to the β-position, consecutively.This method was applied to the synthesis of some alkaloids such as (+/-)-mesembrine.

A New Facile Method for Construction of β-Arylpyrrolidine Rings and Its Application to Synthesis of (+/-)-Mesembrine

Lewis acid treatment of dimethyl N-methoxycarbonyl-N-methoxymethylaminomalonate together with aryl olefins afforded α,α-N-tris(methoxycarbonyl)-β-arylpyrrolidines, and one of the products was successfully converted to (+/-)-mesembrine.