126632-45-9Relevant academic research and scientific papers
Synthesis and biological activity of open-chain analogues of 5,6,7,8- tetrahydrofolic acid-potential antitumor agents
Bigham,Hodson,Mallory,Wilson,Duch,Smith,Ferone
, p. 1399 - 1410 (2007/10/02)
This study describes the synthesis and in vitro antitumor activity of inhibitors of purine de novo biosynthesis that are analogues of N-[4-[[3- (2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]amino]benzoyl-L-glutamic acid (5-DACTHF). Benzene ring subs
Substituted glutamic acids
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, (2008/06/13)
The present invention provides a compound of formula (I): STR1 wherein R1 is hydrogen, C1-4 alkyl, acetyl or formyl; R2 and R3 are the same or different and are hydrogen or C1-4 alkyl; R4 i
