1266323-49-2

Upstream product

• 1266231-63-3 tert-butyl (1S,3R,5S)-3-[(benzylamino)methyl]-2-azabicyclo[3.1.0]hexane-2-carboxylate 
• 100-46-9 benzylamine 
• 1266231-62-2 tert-butyl (1S,3R,5S)-3-(hydroxymethyl)-2-azabicyclo[3.1.0]hexane-2-carboxylate 
• 871727-40-1 2-tert-butyl 3-ethyl (1S,3R,5S)-2-azabicyclo[3.1.0]hexane-2,3-dicarboxylate 
• 128811-31-4 tert-butyl (2R)-2-<<(tert-butyl)dimethylsilyloxy>methyl>-5-oxopyrrolidine-1-carboxylate 
• 1452400-40-6 tert-butyl (2R)-2-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2,3-dihydro-1H-pyrrole-1-carboxylate 

Downstream Products

• 1266231-72-4 tert-butyl [(1S)-2-{[(1S)-1-cyclohexyl-2-{(1aS,4S,6aR,7aS)-4-[(4R)-3,4-dihydro-2H-chromen-4-ylcarbamoyl]octahydro-5H-cyclopropa[4,5]pyrrolo[1,2-a]pyrazin-5-yl}-2-oxoethyl]amino}-1-methyl-2-oxoethyl]methylcarbamate 
• 1266231-65-5 methyl (1aS,4S,6aR,7aS)-5-benzyloctahydro-1H-cyclopropa[4,5]pyrrolo[1,2-a]pyrazine-4-carboxylate 
• 1452400-42-8 methyl (1aS,4R,6aR,7aS)-5-benzyloctahydro-1H-cyclopropa[4,5]pyrrolo[1,2-a]pyrazine-4-carboxylate 

Relevant academic research and scientific papers

Design, stereoselective synthesis, and biological evaluation of novel tri-cyclic compounds as inhibitor of apoptosis proteins (IAP) antagonists

We recently reported the discovery of octahydropyrrolo[1,2-a]pyrazine A as a lead compound for an inhibitor of apoptosis proteins (IAP) antagonist. To develop IAP antagonists with favorable PK profiles, we designed novel tri-cyclic compounds, octahydro-1H