1266334-07-9Relevant academic research and scientific papers
Synthesis of 2-keto-imidazoles utilizing N -arylamino-substituted N-heterocyclic carbenes
Zarganes-Tzitzikas, Tryfon,Neochoritis, Constantinos G.,Stephanidou-Stephanatou, Julia,Tsoleridis, Constantinos A.
, p. 1468 - 1471 (2011)
A new method for the synthesis of 2-aroyl-, 2-heteroaroyl-, and 2-cinnamoyl-substituted imidazoles in very good yields has been developed. The reaction employs novel nitrogen heterocyclic carbenes (NHCs), namely, N-arylamino-substituted NHCs, formed in situ from the corresponding imidazolium salts, and subsequent reaction with aromatic, heteroaromatic, and cinnamic aldehydes without utilizing transition metals or expensive specialized catalysts.(Figure Presented)
