1266343-30-9

Basic information

• Product Name: 5-broMo-4-chloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine
• Synonyms: 7-Bromo-6-chloro-9-methyl-7-deazapurine, 97%;7H-Pyrrolo[2,3-d]pyrimidine, 5-bromo-4-chloro-7-methyl-;JR-14014, 5-Bromo-4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine, 95%
• CAS NO: 1266343-30-9
• Molecular Formula: C₇H₅BrClN₃
• Molecular Weight: 246.4917
• Product Categories: Aromatics;Bases & Related Reagents;Heterocycles;Intermediates;Nucleotides
• Mol File: 1266343-30-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 359.5±37.0 °C(Predicted)
• Appearance: /
• Density: 1.90±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.45±0.30(Predicted)
• CAS DataBase Reference: 5-broMo-4-chloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-broMo-4-chloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine(1266343-30-9)
• EPA Substance Registry System: 5-broMo-4-chloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine(1266343-30-9)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 1266343-30-9(Hazardous Substances Data)

Usage

Chemical Properties

5-broMo-4-chloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine is Light Brown Solid

Uses

5-broMo-4-chloro-7-Methyl-7H-pyrrolo[2,3-d]pyriMidine is used in the preparation of indoline derivatives as PERK inhibitors.

Upstream product

• 3680-69-1 4-chloro-1H-pyrrolo[2,3-d]pyrimidine 
• 7781-10-4 4-Chlor-7-methyl-7H-pyrrolo<2,3-d>pyrimidin 

Downstream Products

• 1069473-61-5 4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid 
• 1266343-32-1 7-methyl-4-(phenylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid 
• 1266343-34-3 N-(2-aminophenyl)-7-methyl-4-(phenylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide 
• 1266341-96-1 5-(1H-1,3-benzodiazol-2-yl)-7-methyl-N-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1337530-96-7 7-methyl-5-[1-(phenylacetyl)-2,3-dihydro-1H-indol-5-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1337532-51-0 5-bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1337531-83-5 7-methyl-5-{1-[(2,3,5-trifluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1337531-89-1 1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-fluoro-5-(trifluoromethyl)phenyl]ethanone 
• 1337531-36-8 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-[3-(trifluoromethyl)phenyl]ethanone 
• 1337531-42-6 7-methyl-5-(1-{[3-(methyloxy)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1337531-38-0 5-{1-[(3-chlorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 
• 1337531-39-1 5-{1-[(2-chlorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine 

Relevant articles and documents

A critical evaluation of pyrrolo[2,3-d]pyrimidine-4-amines as Plasmodium falciparum apical membrane antigen 1 (AMA1) inhibitors

We have determined that a previously reported class of pyrrolo[2,3-d]pyrimidine-4-amines exhibit low binding to apical membrane antigen 1 (AMA1) and suffer from unattractive qualities, such as aggregation. We attempted to remove these traits by generating

Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro- 1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)

Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states. Evidence that PERK is implicated in tumori-genesis and cancer cell survival stim

PYRROLOPYRIMIDINE DERIVATIVES AS POTASSIUM CHANNEL MODULATORS

The present invention relates to pyrrolopyrimidine derivatives of formula(I). They have activation activities of potassium channels as the SK channels, and are useful in the treatment or prevention of disorders and diseases in which potassium channels are