1266386-01-9Relevant articles and documents
Modification of conditions for the selective preparation of 2-amino-3-cyano-4-phenylpyridines
Alvarez-Pere, Monica,Marco-Contelles, Jose
, p. 283 - 296 (2011)
We herein describe the modification of the experimental conditions for the synthesis of certain 2-amino-4-aryl-3-cyanopyridines from benzaldehyde, malononitrile, ammonium acetate and aminoketones. The outcome of the reaction proved to be highly dependent on the experimental procedure, occasionally giving rise to metaphthalodinitriles. Mechanistical proposals are also reported, in order to explain the observed dependence on the procedure. ARKAT-USA, Inc.