1266386-30-4

Basic information

• Product Name: 6-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
• Synonyms: 6-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
• CAS NO: 1266386-30-4
• Molecular Formula: C₁₂H₁₃IN₂O
• Molecular Weight: 328.14889
• Mol File: 1266386-30-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 74-77 °C
• Boiling Point: 426.2±35.0 °C(Predicted)
• Appearance: /
• Density: 1.82±0.1 g/cm3(Predicted)
• PKA: 0.33±0.30(Predicted)
• CAS DataBase Reference: 6-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole(1266386-30-4)
• EPA Substance Registry System: 6-iodo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole(1266386-30-4)

Safety Data

• Hazardous Substances Data: 1266386-30-4(Hazardous Substances Data)

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 261953-36-0 6-Iodo-1H-indazole 

Downstream Products

• 944835-85-2 2-{(1H-indazol-6-yl)thio}-N-methylbenzamide 

Relevant articles and documents

Safe, Scalable, Inexpensive, and Mild Nickel-Catalyzed Migita-Like C?S Cross-Couplings in Recyclable Water

A new approach to C?S couplings is reported that relies on nickel catalysis under mild conditions, enabled by micellar catalysis in recyclable water as the reaction medium. The protocol tolerates a wide range of heteroaromatic halides and thiols, including alkyl and heteroaryl thiols, leading to a variety of thioethers in good isolated yields. The method is scalable, results in low residual metal in the products, and is applicable to syntheses of targets in the pharmaceutical area. The procedure also features an associated low E Factor, suggesting a far more attractive entry than is otherwise currently available, especially those based on unsustainable loadings of Pd catalysts.

Pyridinium p-toluenesulfonate: A mild and efficient catalyst for the regioselective tetrahydropyranylation of indazole derivatives under solvent-free conditions

An efficient and regioselective tetrahydropyranyl (THP) protection on substituted 1H-indazoles in solution phase as well as under solvent-free conditions catalyzed by microwave irradiation in the presence of pyridinium p-toluenesulfonate (PPTS) as mild catalyst.