126643-06-9

Upstream product

• 831-91-4 Benzyl phenyl sulfide 
• 137569-34-7 4-Phenyl-butyric acid 2,6-di-tert-butyl-4-methoxy-phenyl ester 
• 137569-22-3 2,6-di-t-butyl-4-methoxyphenyl 4-phenyl-2-butenoate 
• 18496-54-3 phenylbutyric acid chloride 
• 137569-29-0 t-butyl (2S,5S,1'R)-5-<1'-benzyl-2'-(2,6-di-t-butyl-4-methoxyphenoxycarbonyl)ethyl>-2-(t-butyl)-3-methyl-4-oxo-1-imidazolidinecarboxylate 
• 137569-37-0 (3R,2'S,5'S)-3-<1'-(t-butoxycarbonyl)-2'-(t-butyl)-3'-methyl-4'-oxo-5'-imidazolidinyl>-4-phenylbutanoic acid 
• 126587-40-4 [(3S,4R)-6-Oxo-4-(phenyl-phenylsulfanyl-methyl)-tetrahydro-pyran-3-yl]-carbamic acid tert-butyl ester 
• 126587-37-9 (Z)-(S)-4-tert-Butoxycarbonylamino-5-hydroxy-pent-2-enoic acid methyl ester 
• 124085-71-8 (2Z,4S)-4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-penten-5-olide 
• 126587-36-8 (4S)-1,1-dimethylethyl 4-<(Z)-3'-methoxy-3'-oxo-1'-propenyl>-2,2-dimethyl-3-oxazolidinecarboxylate 

Relevant academic research and scientific papers

SYNTHESIS OF ACYCLIC ANALOGUES OF KAINOIDS AND NEUROEXCITATORY ACTIVITY

Four configurational isomers of 3-benzylglutamic acid, acyclic analogues of kainoids were synthesized to examine their structure-activity relationship.

Acyclic analogs of kainoids: Their syntheses and depolarizing activities

Four stereoisomers of the β-benzylglutamic acids were synthesized by the Michael addition of benzylphenylsulfide to protected (4S)- and (4R)-4-amino-2-penten-5-olide and to protected (2S)- and (2R)-3-dehydro-2-hydroxymethyl-5-pyrrolidone. The β-methallyl- and β-isobutylglutamic acids were also synthesized in a similar manner. The depolarizing activities of these synthesized compounds were observed.

threo-3-Alkyl- and -Arylglutamic Acid Derivatives by Michael Additions of Boc-BMI Li-Enolates to 2,6-Di-t-butyl-4-methoxyphenyl Alkenoates On the Diastereoselectivity of the Coupling of Trigonal Centers Involving Heterocyclic Li-Enolates

The conjugated esters 5, 6, 8, 9 mentioned in the title are prepared from the corresponding aryl acetate 4 and aldehydes by aldol condensation (direct enoylation of the hindered phenol with the corresponding unsaturated acid chlorides gave only poor yield