126643-37-6 Usage
Uses
Used in Thyroid Research:
KT5823 is used as a protein kinase inhibitor for increasing TSH-induced NIS expression and iodide uptake in thyroid cells, which can help in understanding the mechanisms of thyroid function and developing potential therapeutic strategies for thyroid-related disorders.
Used in Neurobiology Research:
KT5823 is used as a cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) inhibitor in cortical cultures, cortical neurons, and mouse brain capillary endothelial cells. This application aids in studying the role of PKG in neuronal signaling and function, as well as its potential involvement in neurological disorders.
Used in Smooth Muscle Research:
KT5823 is used to abolish cGMP-induced relaxation in smooth muscle cells, which can help researchers investigate the mechanisms of smooth muscle contraction and relaxation, and their implications in various physiological and pathological processes.
Used in Cell Cycle Studies:
KT5823 is used to arrest human skin fibroblast cell cycle after the G0/G1 boundary, providing a valuable tool for studying cell cycle regulation and its impact on cell growth, differentiation, and apoptosis.
Biological Activity
Selective inhibitor of protein kinase G (K i values are 0.23, 4 and > 10 μ M for inhibition of PKG, PKC and PKA respectively). Inhibits SNP-stimulated PKG activity with an IC 50 of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 μ M. Also available as part of the Mixed Kinase Inhibitor Tocriset? .
Biochem/physiol Actions
Cell permeable: yes
References
1) Kase et al. (1987), K252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases; Biochem. Biophys. Res. Commun., 142 436
2) Gadbois et al. (1992), Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells; Proc. Natl. Acad. Sci. USA, 89 8626
3) Murthy et al. (1995), Interaction of cA-kinase and cG-kinase in mediating relaxation of dispersed smooth muscle cells; Am. J. Physiol., 268 C171
Check Digit Verification of cas no
The CAS Registry Mumber 126643-37-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,6,6,4 and 3 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 126643-37:
(8*1)+(7*2)+(6*6)+(5*6)+(4*4)+(3*3)+(2*3)+(1*7)=126
126 % 10 = 6
So 126643-37-6 is a valid CAS Registry Number.
