1266583-87-2Relevant academic research and scientific papers
Modular amino acids and β-amino alcohol-based chiral ligands for enantioselective addition of diethylzinc to aromatic aldehydes
Gou, Shaohua,Ye, Zhongbin,Gou, Guangjun,Feng, Mingming,Chang, Jing
experimental part, p. 110 - 116 (2012/06/18)
Enantioselective addition of diethylzinc to a series of aromatic aldehydes was developed using a modular amino acids and ${bf beta}$-amino alcohol-based chiral ligand (2R)-N-[(1R,2S)-1-hydroxy-1-phenylpropan-2-yl]-3- phenyl-2-(tosylamino) propanamide (1f) without using titanium complex. The catalytic system employing 15 mol% of 1f was found to promote the addition of diethylzinc (ZnEt2) to a wide range of aromatic aldehydes with electron-donating and electron-withdrawing substituents, giving up to 97% ee of the corresponding secondary alcohol under mild conditions.
