126680-71-5

Upstream product

• 85-44-9 phthalic anhydride 
• 87-41-2 2-benzofuran-1(3H)-one 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 612-14-6 phthalyl alcohol 
• 81168-17-4 2-(tert-butyldimethylsiloxymethyl)benzyl alcohol 

Downstream Products

• 149636-63-5 tert-butyldimethyl(2-vinylbenzyloxy)silane 
• 86867-62-1 ethyl 3-(2-formylphenyl)acrylate 
• 1437311-40-4 C₂₁H₂₂O₃ 
• 1437311-34-6 1-(2-(1-(allyloxy)prop-2-yn-1-yl)phenyl)propan-1-ol 
• 1437311-36-8 (2-(1-(allyloxy)prop-2-yn-1-yl)phenyl)(phenyl)methanol 
• 1437311-38-0 (2-(1-(allyloxy)-4-(benzyloxy)but-2-yn-1-yl)phenyl)methanol 
• 1437311-23-3 (2-(1-(allyloxy)prop-2-yn-1-yl)phenyl)methanol 
• 1437311-43-7 C₁₆H₁₉NO 
• 1437311-44-8 N-(2-(1-(allyloxy)prop-2-yn-1-yl)benzyl)-1-phenylmethanamine 
• 1437311-11-9 3-allyl-2-benzyl-3-methyl-2,3-dihydroisoquinolin-4(1H)-one 
• 1437311-25-5 (2-(1-((2-methylallyl)oxy)prop-2-yn-1-yl)phenyl)methanol 
• 1437311-27-7 (2-(1-(but-2-en-1-yloxy)prop-2-yn-1-yl)phenyl)methanol 
• 1437311-29-9 (2-(1-(but-2-en-1-yloxy)prop-2-yn-1-yl)phenyl)methanol 

Relevant academic research and scientific papers

Direct Intramolecular Aminoboration of Allenes

Direct intramolecular aminoboration of sulfonamidoallenes was realized using BCl3 as a boron source. The reactions benefited from the interaction between BCl3 and sulfonamides and provided a variety of borylvinyl heterocycles in good isolated yields. When chiral substrates were involved in the reactions, high stereoselectivity was observed, as can be ascertained by single-crystal X-ray diffraction experiments. Derivatization of the thus-obtained borylvinyl compounds proceeded readily, and different functionalities could be obtained via oxidation, halogenation, and Suzuki coupling reactions.

INHIBITORS OF ADENYLATE-FORMING ENZYME MENE

Provided herein are compounds of Formula (I) and pharmaceutically acceptable salts or tautomers thereof which may inhibit adenylate-forming enzymes. Also provided are pharmaceutical compositions, kits, uses, and methods involving the inventive compounds for the treatment and/or prevention of an infectious disease (e.g., bacterial infection (e.g., tuberculosis, methicillin- resistant Staphylococcus aureus)).

PPAR AGONISTS, COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF

Provided herein are compounds of formula (I) useful for the treatment of PPAR-delta related diseases (e.g. mitochondrial diseases, muscular diseases, vascular diseases, demyelinating diseases and metabolic diseases).

Facile synthesis of isochromanones and isoquinolones by AuCl3 catalyzed cascade triggered by an internal nucleophile

Synthesis of isochromanones and isoquinolones comprising a quaternary center with high diastereoselectivity was realized via a AuCl3 catalyzed tandem intramolecular exo-dig heterocyclization/enol isomerization/Claisen rearrangement sequence in

Synthetic studies on the solanacol ABC ring system by cation-initiated cascade cyclization: Implications for strigolactone biosynthesis

We report a new method for constructing the ABC ring system of strigolactones, in a single step from a simple linear precursor by acid-catalyzed double cyclization. The reaction proceeds with a high degree of stereochemical control, which can be qualitatively rationalized using DFT calculations. Our concise synthetic approach offers a new model for thinking about the (as yet) unknown chemistry that is employed in the biosynthetic pathways leading to this class of plant hormones.

Efficient synthesis of the spiroacetal core of paecilospirone via oxidative radical cyclisation

The spiroacetal core of the microtubule assembly inhibitor paecilospirone has been prepared using two separate oxidative cyclisation methods. Georg Thieme Verlag Stuttgart - New York.

Tandem Henry/oxa-Michael route to the 1,3-disubstituted-1,3-dihydrobenzo[c] furan system

The reaction of ortho-formyl cinnamates and ortho-formyl-α- benzalketones with suitably substituted alkylnitro compounds in the presence of 1,1,3,3-tetramethylguanidine results in the formation of 1,3-disubstituted dihydroisobenzofurans. The reaction mechanism entails a base-mediated nitronate addition to the aryl formyl group followed by intramolecular alcoholate addition to the unsaturated component that then affords the isobenzofuran system.

Synthesis of novel isochromene derivatives by tandem Ugi reaction/ nucleophilic substitution

Unprecedented 3-amino-4-amido-lH-isochromenes have been prepared in three steps from protected ortho-(hydroxymethyl)benzaldehyde, with the introduction of three diversity inputs, through a Ugi reaction followed by intramolecular nucleophilic substitution. Georg Thieme Verlag Stuttgart.

NOVEL CURCUMIN DERIVATIVE

The present invention provides a novel compound that is structurally similar to curcumin and has a suppressive effect on Aβ aggregation, a degradative effect on Aβ aggregates, an inhibitory effect on β-secretase, and a protective effect on neurons. The novel compound is a compound represented by the following general formula (Ia) or a salt thereof: wherein R1 represents a 4-hydroxy-3-methoxyphenyl group or the like, and R2 represents a 1H-indol-6-yl group or the like.

Bromoallenes as allyl dication equivalents in the presence or absence of palladium(0): Direct construction of bicyclic sulfamides containing five- to eight-membered rings by tandem cyclization of bromoallenes

A highly regioselective synthesis of bicyclic sulfamides is described. Based on our recent discovery that bromoallenes can act as allyl dication equivalents in the presence of a palladium catalyst and alcohol, we investigated tandem cyclization of bromoal