1266804-81-2

Basic information

• Product Name: (RS)-1-(benzo[d][1,3]dioxol-5-yl)-2-bromobutanone
• Synonyms: (RS)-1-(benzo[d][1,3]dioxol-5-yl)-2-bromobutanone
• CAS NO: 1266804-81-2
• Molecular Weight: 271.111
• Mol File: 1266804-81-2.mol

Chemical Properties

• CAS DataBase Reference: (RS)-1-(benzo[d][1,3]dioxol-5-yl)-2-bromobutanone(CAS DataBase Reference)
• NIST Chemistry Reference: (RS)-1-(benzo[d][1,3]dioxol-5-yl)-2-bromobutanone(1266804-81-2)
• EPA Substance Registry System: (RS)-1-(benzo[d][1,3]dioxol-5-yl)-2-bromobutanone(1266804-81-2)

Safety Data

• Hazardous Substances Data: 1266804-81-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
(RS)-1-(benzo[d][1,3]dioxol-5-yl)-2-bromobutanone is used as an intermediate in the synthesis of various pharmaceutical drugs. Its unique structure and reactivity contribute to the development of new medications with potential therapeutic benefits.
Used in Organic Chemistry Research:
In the field of organic chemistry, (RS)-1-(benzo[d][1,3]dioxol-5-yl)-2-bromobutanone serves as a key compound for studying reaction mechanisms, exploring new synthetic pathways, and understanding the properties of related chemical compounds. Its application in research aids in the advancement of chemical knowledge and the discovery of novel applications.
Further studies and testing are necessary to fully comprehend the properties and potential uses of (RS)-1-(benzo[d][1,3]dioxol-5-yl)-2-bromobutanone, as its wide-ranging applications in different industries are still being explored.

Upstream product

• 63740-97-6 1-(2H-benzo[3,4-d]1,3-dioxolen-5-yl)butan-1-one 

Relevant articles and documents

Enantioconvergent Cu-Catalyzed Radical C-N Coupling of Racemic Secondary Alkyl Halides to Access α-Chiral Primary Amines

α-Chiral alkyl primary amines are virtually universal synthetic precursors for all other α-chiral N-containing compounds ubiquitous in biological, pharmaceutical, and material sciences. The enantioselective amination of common alkyl halides with ammonia is appealing for potential rapid access to α-chiral primary amines, but has hitherto remained rare due to the multifaceted difficulties in using ammonia and the underdeveloped C(sp3)-N coupling. Here we demonstrate sulfoximines as excellent ammonia surrogates for enantioconvergent radical C-N coupling with diverse racemic secondary alkyl halides (>60 examples) by copper catalysis under mild thermal conditions. The reaction efficiently provides highly enantioenrichedN-alkyl sulfoximines (up to 99% yield and >99% ee) featuring secondary benzyl, propargyl, α-carbonyl alkyl, and α-cyano alkyl stereocenters. In addition, we have converted the masked α-chiral primary amines thus obtained to various synthetic building blocks, ligands, and drugs possessing α-chiral N-functionalities, such as carbamate, carboxylamide, secondary and tertiary amine, and oxazoline, with commonly seen α-substitution patterns. These results shine light on the potential of enantioconvergent radical cross-coupling as a general chiral carbon-heteroatom formation strategy.

Immunoassay for pyrrolidinophenones

The invention describes antibodies that bind molecules of the pyrrolidinophenone class of synthetic drugs. The antibodies are derived from novel chemical intermediates, haptens and immunogens and are used in methods and kits to detect and quantify pyrrolidinophenones.