126725-04-0Relevant articles and documents
Benzene compounds having two pyridazinone substituents
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, (2008/06/13)
The invention relates to pyridazinone derivatives which have inotropic, vasodilator and bronchodilator activity. The compounds of the invention are described by formula (I): STR1 wherein: R1 is hydrogen or methyl; R2 is hydrogen or methyl; and represent double or single bonds; and the benzene ring is para- or meta-substituted; and pharmaceutically acceptable salts thereof.
1,4-Bis(3-oxo-2,3-dihydropyridazin-6-yl)benzene Analogues: Potent Phosphodiesterase Inhibitors and Inodilators
Coates, William J.,Prain, H. Douglas,Reeves, Martin L.,Warrington, Brian H.
, p. 1735 - 1741 (2007/10/02)
1,4-Bis(3-oxo-2,3-dihydropyridazin-6-yl)benzene and a series of related bis(azinone) compounds were synthesized.These novel compounds were evaluated for inhibition of the low Km, cAMP-selective, cGMP-inhibited phosphodiesterase (PDE III) derive