126728-20-9

Basic information

• Product Name: 2,4-DICHLOROPYRIDO[2,3-D]PYRIMIDINE
• Synonyms: 2,4-dichloropyrido[2,3-d]...;Pyrido[2,3-d]pyrimidine,2,4-dichloro-;2,4-DICHLOROPYRIDO[2,3-D]PYRIMIDINE
• CAS NO: 126728-20-9
• Molecular Formula: C₇H₃Cl₂N₃
• Molecular Weight: 200.02
• Mol File: 126728-20-9.mol
• Article Data: 23

Chemical Properties

• Melting Point: 157-158 °C (decomp)
• Appearance: /
• Density: 1.573 g/cm³
• Refractive Index: 1.682
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.38±0.30(Predicted)
• CAS DataBase Reference: 2,4-DICHLOROPYRIDO[2,3-D]PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DICHLOROPYRIDO[2,3-D]PYRIMIDINE(126728-20-9)
• EPA Substance Registry System: 2,4-DICHLOROPYRIDO[2,3-D]PYRIMIDINE(126728-20-9)

Safety Data

• Hazardous Substances Data: 126728-20-9(Hazardous Substances Data)

Usage

General Description

2,4-Dichloropyrido[2,3-d]pyrimidine is a chemical compound that belongs to the class of pyrimidine derivatives. It is a yellow crystalline solid with the molecular formula C6H3Cl2N3. 2,4-DICHLOROPYRIDO[2,3-D]PYRIMIDINE is used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It has also been studied for its potential use in the treatment of cancer and as a precursor for the development of novel drugs. Additionally, it has been investigated for its herbicidal and pesticidal properties. However, it is important to handle this compound with caution as it can be harmful if ingested or inhaled, and it may cause skin and eye irritation.

InChI:InChI=1/C7H3Cl2N3/c8-5-4-2-1-3-10-6(4)12-7(9)11-5/h1-3H

Upstream product

• 7463-30-1 N-(2-pyridyl-3-methyl)acetamide 
• 5345-47-1 2-aminopyridin-3-carboxylic acid 
• 21038-66-4 2,4-dihydroxy-pyrido[2,3-d]pyrimidine 
• 21038-66-4 1H-Pyrido[2,3-d]pyrimidine-2,4-dione 

Downstream Products

• 1332472-85-1 2-(5-methyl-6-phenyl-pyridin-2-yl)-pyrido[2,3-d]pyrimidine 
• 766500-12-3 2-(3-hydroxyphenyl)-4-morpholinopyrido[2,3-d]pyrimidine 
• 1542142-20-0 2-(3-(hydroxymethyl)phenyl)-4-morpholinopyrido[2,3-d]pyrimidine 
• 1477917-10-4 pyrido[2,3-d]pyrimidin-2,4-bis(4-phenylbutyl)amine hydroselenite 
• 1032902-86-5 C₃₁H₄₂N₆O₃S 
• 1032902-87-6 C₃₁H₃₈N₆O₃S 

Relevant articles and documents

The discovery and optimisation of pyrido[2,3-d]pyrimidine-2,4-diamines as potent and selective inhibitors of mTOR kinase

We describe a novel series of potent inhibitors of the kinase activity of mTOR. The compounds display good selectivity relative to other PI3K-related kinase family members and, in cellular assays, inhibit both mTORC1 and mTORC2 complexes and exhibit good antiproliferative activity.

Compounds containing pyrimidine heterocyclic structures and preparation methods and applications thereof

Compounds containing pyrimidine heterocyclic structures and preparation methods and applications thereof, belonging to the field of pharmaceutical technology, the present invention relates to compounds containing pyrimidine heterocyclic structures shown i

2,4-quinazolinediamine derivatives, and preparation method and application thereof

The invention discloses 2,4-quinazolinediamine derivatives, and a preparation method and application thereof, belonging to the field of medicines and preparation and application thereof. The 2,4-quinazolinediamine derivatives comprises compounds as shown in a formula (I) which is described in the specification and a solvate, hydrate, tautomer and pharmaceutically acceptable salt thereof. Test results show that the 2,4-quinazolinediamine derivatives have strong Wolbachia resisting activity; and in the derivatives, 2-isopropylamido substitution has good effect, and compounds with better Wolbachia resisting activity can be obtained by changing a 4-amido group. The compounds have activity in resisting plasmodia, Wolbachia and bacteria.