126740-79-2

Upstream product

• 99049-62-4 2-azido-2-deoxy-3,4,6-tri-O-benzyl-α-D-glucopyranosyl trichloroacetimidate 
• 126740-60-1 tert-butyldimethylsilyl 2-azido-2-deoxy-4,6-O-p-methoxybenzylidene-β-D-galactopyranoside 
• 94715-52-3 tert-butyldimethylsilyl-2-azido-2-desoxy-β-D-galactopyranosid 
• 2186-92-7 p-Anisaldehyde dimethyl acetal 

Downstream Products

• 126740-61-2 tert-butyldimethylsilyl 2-azido-3-O-(2-azido-3,4,6-tri-O-benzyl-β-D-glucopyranosyl)-2-deoxy-β-D-galactopyranoside 

Relevant academic research and scientific papers

SYNTHESIS OF GLYCOPEPTIDES OF THE MUCIN TYPE CONTAINING A β-D-GlcpNAc-(1->3)-D-GalpNAc UNIT

Mucin-type O-glycopeptides containing the β-D-GlcpNAc-(1->3)-D-GalpNAc core unit were synthesised from 2-azido-2-deoxy-D-glucose, 2-azido-2-deoxy-D-galactose, 2-azido-2-deoxylactose, and L-serine precursors, using the trichloroacetimidate method.Thus, β-D-GlcpNAc-(1->3)-α-D-GalpNAc-(1->3)-Ser (1) and a derivative of β-D-Galp-(1->4)-β-D-GlcpNAc-(1->6)-3)>-α-D-GalpNAc-(1->3)-Ser (2) were obtained.A precursor of 1 having HO-4,6 of the 2-azido-2-deoxy-D-galactose residue unsubstituted was a valuable intermediate for the synthesis of 2 due to regioselective glycosylation at O-6.Regioselectivity in this reaction was not observed for precursors having a tert-butyldimethylsilyl group at O-1 instead of a protected L-serine moiety.