126745-67-3Relevant academic research and scientific papers
Highly chemoselective catalytic hydrogenation of unsaturated ketones and aldehydes to unsaturated alcohols using phosphine-stabilized copper(I) hydride complexes
Chen, Jian-Xin,Daeuble, John F.,Brestensky, Donna M.,Stryker, Jeffrey M.
, p. 2153 - 2166 (2000)
A base metal hydrogenation catalyst composed of the phenyldimethylphosphine-stabilized copper(I) hydride complex provides for the highly chemoselective hydrogenation of unsaturated ketones and aldehydes to unsaturated alcohols, including the regioselective 1,2-reduction of α,β- unsaturated ketones and aldehydes to allylic alcohols. The active catalyst can be derived in situ by phosphine exchange using commercial [(Ph3P)CuH]6 or from the reaction of copper(l) chloride, sodium tert-butoxide, and dimethylphenylphosphine under hydrogen. The catalyst derived from 1,1,1- tris(diphenylphosphinomethyl)ethane is mechanistically interesting but less synthetically useful. (C) 2000 Elsevier Science Ltd.
