1267579-87-2

Upstream product

• 367966-45-8 (2S,4S)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1,2-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) 2-methyl ester 
• 791602-93-2 (2S,4S)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-(hydroxymethyl)-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester 
• 74844-91-0 (2S,4S)-N-tert-butoxycarbonyl-4-hydroxyproline methyl ester 
• 1267580-04-0 (2S, 4R)-tert-butyl-2-(bis(p-tolylthio)methyl)-4-(3-(3, 5-bis(trifluoromethyl)phenyl)thioureido)pyrrolidine-1-carboxylate 
• 1267580-03-9 (2S, 4R)-tert-butyl 4-amino-2-(bis(p-tolylthio)methyl)pyrrolidine-1-carboxylate 
• 1267580-02-8 (2S, 4R)-tert-butyl 4-azido-2-(bis(p-tolylthio)methyl)pyrrolidine-1-carboxylate 
• 1267580-01-7 (2S, 4S)-tert-butyl 2-(bis(p-tolylthio)methyl)-4-(methylsulfonyloxy)pyrrolidine-1-carboxylate 
• 1267579-99-6 (2S, 4S)-tert-butyl 2-(bis(p-tolylthio)methyl)-4-(tert-butyldimethylsilyloxy)pyrrolidine-1-carboxylate 
• 1267579-95-2 (2S, 4S)-tert-butyl 2-(bis(p-tolylthio)methyl)-4-(tert-butyldimethylsilyloxy)pyrrolidine-1-carboxylate 
• 401564-17-8 (2S,4S)-1-(tert-butoxycarbonyl)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylic acid 

Relevant academic research and scientific papers

4-aminothioureaprolinal dithioacetal as a catalyst for highly enantioselective michael additions of ketones and aldehydes to nitroolefins

4-Aminothioureaprolinal dithioacetal 4a is a highly efficient catalyst for the asymmetric Michael addition of ketones and aldehydes to nitroolefins requiring only 3 mol-% catalyst loading. The reactions proceeded smoothly and gave syn selective adducts with excellent yields (up to 98a% yield), diastereoselectivity (up to >99:1adr), and enantioselectivity (up to 99a%aee) under solvent free conditions at room temperature. This extremely simple and practical procedure increases the attractiveness of this reaction. 4-Aminothioureaprolinal dithioacetal 4a is a highly efficient catalyst for asymmetric Michael additions of ketones and aldehydes to nitroolefins. Using only 3 mol-% catalyst loading, reactions proceededsmoothly and gave syn selective adducts in excellent yields with excellent diastereoselectivity and enantioselectivity under solvent-free conditions at room temperature.