1267635-75-5

Upstream product

• 60857-16-1 N-(4-methoxybenzyl)glycine ethyl ester 
• 630413-89-7 1-[(4-methoxyphenyl)methyl]-4-amino-5-ethoxycarbonylimidazole 
• 1267635-73-3 C₁₆H₁₆F₃N₃O₄ 
• 1267635-74-4 C₁₇H₁₈F₃N₃O₄ 

Downstream Products

• 1267635-79-9 C₁₇H₁₃ClN₄O 
• 1267635-80-2 C₁₉H₁₇ClN₄O 
• 1267635-78-8 C₂₅H₂₁ClN₄O₂ 
• 1267635-77-7 C₁₉H₁₇ClN₄O₂ 
• 1267635-76-6 C₂₁H₂₁ClN₄O₅ 

Relevant academic research and scientific papers

DERIVATIVES OF 1-PHENYL-1,5-DIHYDRO-BENZO[B] [1.4]DIAZEPINE-2.4-DIONE AS INHIBITORS OF HIV REPLICATION

Compounds of formula (I) wherein m, R1, R2, R3, X and Y are defined herein, are useful as inhibitors of HIV replication.

Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly

The discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly is described. Synthesis of analogs of the 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione hit established structure-activity relationships. Replacement of the enamine functionality of the hit series with either an imidazole or a pyrazole ring led to compounds that inhibited both capsid assembly and reverse transcriptase. Optimization of the bicyclic benzodiazepine scaffold to include a 3-phenyl substituent led to lead compound 48, a pure capsid assembly inhibitor with improved antiviral activity.