1267640-07-2Relevant academic research and scientific papers
Strained cyclophane macrocycles: Impact of progressive ring size reduction on synthesis and structure
Bogdan, Andrew R.,Jerome, Steven V.,Houk,James, Keith
supporting information; experimental part, p. 2127 - 2138 (2012/03/10)
The synthesis, X-ray crystal structures, and calculated strain energies are reported for a homologous series of 11- to 14-membered drug-like cyclophane macrocycles, representing an unusual region of chemical space that can be difficult to access synthetic
Efficient access to new chemical space through flow-construction of druglike macrocycles through copper-surface-catalyzed azide-alkyne cycloaddition reactions
Bogdan, Andrew R.,James, Keith
supporting information; experimental part, p. 14506 - 14512 (2011/03/20)
A series of 12- to 22-membered macrocycles, with druglike functionality and properties, have been generated by using a simple and efficient copper-catalyzed azide-acetylene cycloaddition reaction, conducted in flow in high-temperature copper tubing, under
