1267640-80-1

Basic information

• Product Name: 4-azidobutan-1-amine hydrochloride
• CAS NO: 1267640-80-1
• Molecular Weight: 150.611
• Mol File: 1267640-80-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-azidobutan-1-amine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-azidobutan-1-amine hydrochloride(1267640-80-1)
• EPA Substance Registry System: 4-azidobutan-1-amine hydrochloride(1267640-80-1)

Safety Data

• Hazardous Substances Data: 1267640-80-1(Hazardous Substances Data)

Upstream product

• 66917-06-4 N-(4-azidobutyl)phthalimide 
• 129392-85-4 N-t-butoxycarbonyl-4-azidobutylamine 
• 88192-20-5 4-azidobutan-1-amine 

Relevant articles and documents

Azido-Desferrioxamine Siderophores as Functional Click-Chemistry Probes Generated in Culture upon Adding a Diazo-Transfer Reagent

This work aimed to undertake the in situ conversion of the terminal amine groups of bacterial desferrioxamine (DFO) siderophores, including desferrioxamine B (DFOB), to azide groups to enable downstream click chemistry. Initial studies trialed a precursor-directed biosynthesis (PDB) approach. Supplementing Streptomyces pilosus culture with blunt-end azido/amine non-native substrates designed to replace 1,5-diaminopentane as the native diamine substrate in the terminal amine position of DFOB did not produce azido-DFOB. Addition of the diazo-transfer reagent imidazole-1-sulfonyl azide hydrogen sulfate to spent S. pilosus medium that had been cultured in the presence of 1,4-diaminobutane, as a viable native substrate to expand the suite of native DFO-type siderophores, successfully generated the cognate suite of azido-DFO analogues. CuI-mediated or strain-promoted CuI-free click chemistry reactions between this minimally processed mixture and the appropriate alkyne-bearing biotin reagents produced the cognate suite of 1,4-disubstituted triazole-linked DFO-biotin compounds as potential molecular probes, detected as FeIII-loaded species. The amine-to-azide transformation of amine-bearing natural products in complex mixtures by the direct addition of a diazo-transfer reagent to deliver functional click chemistry reagents adds to the toolbox for chemical proteomics, chemical biology, and drug discovery.

Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: Structural, biochemical, spectroscopic, and antiviral studies

Outbreaks of acute gastroenteritis caused by noroviruses constitute a public health concern worldwide. To date, there are no approved drugs or vaccines for the management and prophylaxis of norovirus infections. A potentially effective strategy for the development of norovirus therapeutics entails the discovery of inhibitors of norovirus 3CL protease, an enzyme essential for noroviral replication. We describe herein the structure-based design of the first class of permeable, triazole-based macrocyclic inhibitors of norovirus 3C-like protease, as well as pertinent X-ray crystallographic, biochemical, spectroscopic, and antiviral studies.