126775-18-6Relevant academic research and scientific papers
Substituted Pyridazin-3(2 H)-ones as Highly Potent and Biased Formyl Peptide Receptor Agonists
Deora, Girdhar Singh,Qin, Cheng Xue,Vecchio, Elizabeth A.,Debono, Aaron J.,Priebbenow, Daniel L.,Brady, Ryan M.,Beveridge, Julia,Teguh, Silvia C.,Deo, Minh,May, Lauren T.,Krippner, Guy,Ritchie, Rebecca H.,Baell, Jonathan B.
, p. 5242 - 5248 (2019)
Herein we describe the development of a focused series of functionalized pyridazin-3(2H)-one-based formyl peptide receptor (FPR) agonists that demonstrate high potency and biased agonism. The compounds described demonstrated biased activation of prosurvival signaling, ERK1/2 phosphorylation, through diminution of the detrimental FPR1/2-mediated intracellular calcium (Cai2+) mobilization. Compound 50 showed an EC50 of 0.083 μM for phosphorylation of ERK1/2 and an approximate 20-fold bias away from Cai2+ mobilization at the hFPR1.
SYNTHESIS OF SOME NEW PYRIDAZINONES
Kandile, Nadia G.,Ahmed, Effat A.
, p. 829 - 835 (2007/10/02)
The synthesis of 6-methyl-4-(arylmethyl)pyridazine-3(2H)-one and some derivatives are reported using 4,5-dihydro-6-metylpyridazine-3(2H)-one (1) as starting material.
