126784-55-2Relevant academic research and scientific papers
Dynamic Kinetic Resolution of I-Substituted Cyclic β-Ketoesters via Asymmetric Hydrogenation: Constructing Chiral Cyclic β-Hydroxyesters with Three Contiguous Stereocenters
Yang, Dan,Wu, Xiong,Zheng, Xiao-Jie,Xie, Jian-Hua,Zhou, Qi-Lin
, p. 5153 - 5157 (2021/07/20)
An efficient asymmetric hydrogenation of racemic I-substituted cyclic β-ketoesters via dynamic kinetic resolution to provide chiral cyclic β-hydroxy esters with three contiguous stereocenters is reported. Using a chiral spiro iridium catalyst (R)-5 (Ir-SpiroSAP), a series of racemic I-Aryl/alkyl substituted cyclic β-ketoesters were hydrogenated to the corresponding chiral cyclic β-hydroxy esters in high yields (84-97%) with good to excellent enantioselectivities (69->99% ee) and cis,cis-selectivities (up to >99:1).
Total Synthesis of (±)-Waihoensene
Lee, Hongsoo,Kang, Taek,Lee, Hee-Yoon
supporting information, p. 8254 - 8257 (2017/06/30)
The first total synthesis of waihoensene, a tetracyclic diterpene containing an angular triquinane and a six-membered ring, with four contiguous quaternary carbon atoms, was achieved through the tandem cycloaddition reaction of an allenyl diazo substrate containing a six-membered ring via trimethylenemethane (TMM) diyl intermediate.
A SYNTHESIS OF (-)-DEOXYPODOCARPIC ACID METHYL ESTER VIA AN ENZYMATIC ENANTIOSELECTIVE HYDROLYSIS OF THE KEY INTERMEDIATE ENOL ESTER
Sugai, Takeshi,Kakeya, Hideaki,Ohta, Hiromichi,Morooka, Mitsuo,Ohba, Shigeru
, p. 6135 - 6144 (2007/10/02)
(1R,4aR,10aS)-(-)-1-Methoxycarbonyl-1,4a-dimethyl-1,2,3,4,4a,9,10,10a-octahydrophenanthrene (deoxypodocarpic acid methyl ester 1), a useful intermediate for the synthesis of various diterpenes, was synthesized from (R)-(+)-6-ethoxycarbonyl-2,6-dimethyl-1-
