126786-76-3Relevant academic research and scientific papers
A STEREOCONTROLLED APPROACH TO TRI AND TETRASUBSTITUTED CYCLOHEXANONES
Zoretic, Phillip A.,Dickerson, Scott H.,Yu, Byung-Chan,Biggers, Michael S.,Chambers, Robert J.,et al.
, p. 2869 - 2876 (2007/10/02)
A series of reactions utilizing acetals 2-5 with organo cuprates was studied to determine the stereoselectivity of the 1,4-conjugate addition.A 90:10 stereoselectivity was observed from the reaction of lithium or bromomagnesium divinyl cuprate with acetal 5 which generated a facile entry to the tetrasubstituted cyclohexanone 10a via a consecutive 1,4-aonjugate addition - 1,3-alkylation sequence.
