6-amino-5-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-triazin-4-one, commonly known as lamivudine, is a potent antiviral medication that belongs to the class of nucleoside reverse transcriptase inhibitors (NRTIs). It is characterized by a unique structure comprising a triazinone ring, an amino group, and a dihydroxyoxolan-2-yl side chain, which contribute to its antiviral activity. Lamivudine is primarily used to treat chronic hepatitis B and HIV/AIDS by inhibiting the activity of the reverse transcriptase enzyme, essential for viral replication.
12679-86-6
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Basic information
- Product Name: 6-amino-5-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-triazin-4-one
- Synonyms: 6-amino-5-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-triazin-4-one
- CAS NO:12679-86-6
- Molecular Formula: C8H12N4O5
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: N/A
- Mol File: 12679-86-6.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 519.7°Cat760mmHg
- Flash Point: 268.1°C
- Appearance: /
- Density: 2.2g/cm3
- Vapor Pressure: 5.67E-13mmHg at 25°C
- Refractive Index: 1.864
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: 6-amino-5-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-triazin-4-one(CAS DataBase Reference)
- NIST Chemistry Reference: 6-amino-5-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-triazin-4-one(12679-86-6)
- EPA Substance Registry System: 6-amino-5-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-triazin-4-one(12679-86-6)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 12679-86-6(Hazardous Substances Data)
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12679-86-6 Usage
Uses
Used in Antiviral Therapy:6-amino-5-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-triazin-4-one is used as an antiviral agent for the treatment of chronic hepatitis B and HIV/AIDS. It works by inhibiting the reverse transcriptase enzyme, which is crucial for the replication of the virus, leading to a reduction in viral load and improvement in immune function in affected patients.
Used in Antiretroviral Therapy:
In the healthcare industry, 6-amino-5-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-triazin-4-one is used as a key component of antiretroviral therapy for HIV/AIDS. Its incorporation into combination therapies helps to suppress the replication of the virus, manage the progression of the disease, and improve the quality of life for patients living with HIV.
Used in Hepatitis B Treatment:
6-amino-5-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-triazin-4-one is utilized as a therapeutic agent in the treatment of chronic hepatitis B. Its antiviral properties help to control the hepatitis B virus, reducing the risk of liver damage and complications associated with the disease.
Check Digit Verification of cas no
The CAS Registry Mumber 12679-86-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,2,6,7 and 9 respectively; the second part has 2 digits, 8 and 6 respectively.Calculate Digit Verification of CAS Registry Number 12679-86:
(7*1)+(6*2)+(5*6)+(4*7)+(3*9)+(2*8)+(1*6)=126
126 % 10 = 6
So 12679-86-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H12N4O5/c9-7-3(8(16)11-12-10-7)6-5(15)4(14)2(1-13)17-6/h2,4-6,13-15H,1H2,(H3,9,10,11,16)/t2-,4-,5-,6+/m1/s1
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6-amino-5-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-triazin-4-one
