12679-86-6

Basic information

• Product Name: 6-amino-5-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-triazin-4-one
• Synonyms: 6-amino-5-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-triazin-4-one
• CAS NO: 12679-86-6
• Molecular Formula: C8H12N4O5
• Molecular Weight: 0
• Mol File: 12679-86-6.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 519.7°Cat760mmHg
• Flash Point: 268.1°C
• Appearance: /
• Density: 2.2g/cm³
• Vapor Pressure: 5.67E-13mmHg at 25°C
• Refractive Index: 1.864
• CAS DataBase Reference: 6-amino-5-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-triazin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-amino-5-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-triazin-4-one(12679-86-6)
• EPA Substance Registry System: 6-amino-5-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-triazin-4-one(12679-86-6)

Safety Data

• Hazardous Substances Data: 12679-86-6(Hazardous Substances Data)

Usage

General Description

6-amino-5-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-triazin-4-one, also known as lamivudine, is a potent antiviral medication used to treat chronic hepatitis B and HIV/AIDS. It belongs to the class of nucleoside reverse transcriptase inhibitors (NRTIs) and works by inhibiting the activity of the reverse transcriptase enzyme, which is essential for the replication of the virus. 6-amino-5-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-triazin-4-one has a unique structure consisting of a triazinone ring and an amino group, as well as a dihydroxyoxolan-2-yl side chain, which plays a crucial role in its antiviral activity. Lamivudine has been shown to be effective in reducing viral load and improving the immune function in patients with hepatitis B and HIV, making it an essential component of antiretroviral therapy.

InChI:InChI=1/C8H12N4O5/c9-7-3(8(16)11-12-10-7)6-5(15)4(14)2(1-13)17-6/h2,4-6,13-15H,1H2,(H3,9,10,11,16)/t2-,4-,5-,6+/m1/s1