1267907-58-3Relevant articles and documents
Atropisomerism observed in indometacin derivatives
Takahashi, Hideyo,Wakamatsu, Shintaro,Tabata, Hidetsugu,Oshitari, Tetsuta,Harada, Ayako,Inoue, Keizo,Natsugari, Hideaki
supporting information; experimental part, p. 760 - 763 (2011/05/05)
To elucidate the active conformation of indometacin that differentiates between cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), the stereochemistry around the N-benzoylated indole moiety of indometacin was studied. Resolution of stable atropisomers