1267964-81-7

Basic information

• Product Name: C₂₀H₁₇BrO₂
• Synonyms: C₂₀H₁₇BrO₂
• CAS NO: 1267964-81-7
• Molecular Weight: 369.258
• Mol File: 1267964-81-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₁₇BrO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₁₇BrO₂(1267964-81-7)
• EPA Substance Registry System: C₂₀H₁₇BrO₂(1267964-81-7)

Safety Data

• Hazardous Substances Data: 1267964-81-7(Hazardous Substances Data)

Upstream product

• 60108-72-7 1,2-dibromo-4-biphenyl 
• 151-10-0 1,3-Dimethoxybenzene 

Relevant articles and documents

Regioselectivity in the aryne cross-coupling of aryllithiums with functionalized 1,2-dibromobenzenes

Tri- and tetrasubstituted ortho-bromobiaryls have been synthesized in good-to-excellent yields by aryne cross-coupling reactions starting from 1,3-dimethoxybenzene and functionalized 1,2-dibromobenzenes. This study outlines the influence of the 1,2-dibromobenzene precursor as well as the reaction temperature on the outcome of the aryl-aryl bond formation and indicates, in the case of dissymmetrical benzyne precursors, how structural parameters (electronic effects, steric hindrance, temperature, etc.) control the regioselectivity of the aryne cross-coupling reactions. A wide range of o,o′-tri- and-tetrasubstituted biphenyls have been prepared by a transition-metal-free "aryne" cross-coupling starting from 2,6-dimethoxyphenyllithium and various functionalized 1,2-dibromobenzenes. Mechanistic investigations outline the key parameters that govern both the aryl-aryl bond formation and the regioselectivity of the reaction with dissymmetrical aryne precursors. Copyright