1268152-53-9Relevant academic research and scientific papers
Investigation of α-phenylnorstatine and α-benzylnorstatine as transition state isostere motifs in the search for new BACE-1 inhibitors
Wngsell, Fredrik,Nordeman, Patrik,S?vmarker, Jonas,Emanuelsson, Rikard,Jansson, Katarina,Lindberg, Jimmy,Rosenquist, Sa,Samuelsson, Bertil,Larhed, Mats
, p. 145 - 155 (2011/03/17)
Inhibition of the BACE-1 protease enzyme has over the recent decade developed into a promising drug strategy for Alzheimer therapy. In this report, more than 20 new BACE-1 protease inhibitors based on α-phenylnorstatine, α-benzylnorstatine, iso-serine, an
