1268167-75-4Relevant academic research and scientific papers
Bi(iii)-catalyzed aminooxygenation of propargyl amidines to synthesize 2-fluoroalkyl imidazole-5-carbaldehydes and their decarbonylations
Li, Shan,Li, Yajun,Feng, Bin,Liang, Jian,You, Geyun,Liu, Xiaofeng,Xian, Liqing
, p. 6400 - 6403 (2020)
The first example of main group metal Bi(iii)-catalyzed aminooxygenation of fluorinated propargyl amidines was developed to produce 2-fluoroalkyl imidazole-5-carbaldehydes in moderate to excellent yields, in which phenol played a critical role and could be recovered and recycled. In the presence of KOt-Bu, an unconventional decarbonylation occurred on the 2-fluoroalkyl imidazole-5-carbaldehydes.
Copper-mediated trifluoromethylation of heteroaromatic compounds by trifluoromethyl sulfonium salts
Zhang, Cheng-Pan,Wang, Zong-Ling,Chen, Qing-Yun,Zhang, Chun-Tao,Gu, Yu-Cheng,Xiao, Ji-Chang
supporting information; experimental part, p. 1896 - 1900 (2011/04/16)
Copper is king! A convenient method for the synthesis of trifluoromethylated heteroaromatic compounds under mild conditions has been developed based on the observation that 1 can be reduced by certain metals (see scheme). Substrate 1 is assumed to be reduced by copper via a single-electron transfer mechanism, and CuCF3 is the most probable intermediate in this reaction. DMF=N,N-dimethylformamide, Tf=triflate.
