1268240-91-0

Basic information

• Product Name: (S)-N-((S)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-phenylethyl)-2-methylpropane-2-sulfinamide
• Synonyms: (S)-N-((S)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-phenylethyl)-2-methylpropane-2-sulfinamide
• CAS NO: 1268240-91-0
• Molecular Weight: 325.472
• Mol File: 1268240-91-0.mol

Chemical Properties

• CAS DataBase Reference: (S)-N-((S)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-phenylethyl)-2-methylpropane-2-sulfinamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-((S)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-phenylethyl)-2-methylpropane-2-sulfinamide(1268240-91-0)
• EPA Substance Registry System: (S)-N-((S)-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-phenylethyl)-2-methylpropane-2-sulfinamide(1268240-91-0)

Safety Data

• Hazardous Substances Data: 1268240-91-0(Hazardous Substances Data)

Upstream product

• 15186-48-8 2,3-isopropylidene-glyceraldehyde 
• 1262535-90-9 (S_S,E)-N-[(2S)-2,3-(isopropylidenedioxy)propylidene]-2-methyl-2-propanesulfinamide 
• 100-44-7 benzyl chloride 

Downstream Products

• 188130-37-2 C₁₀H₁₅NO₂*ClH 
• 149451-80-9 (2S,3S)-3-(t-butoxycarbonylamino)-4-phenylbutane-1,2-diol 

Relevant articles and documents

Asymmetric synthesis of amines by the knochel-type MgCl2- enhanced addition of benzyl zinc reagents to N -tert -Butanesulfinyl aldimines

The MgCl2-enhanced addition of benzyl zinc reagents to N-tert-butanesulfinyl imines proceeds readily at room temperature to afford the N-tert-butanesulfinyl-protected amine products in good yields and diastereomeric ratios. This method is functional group tolerant in both the imine substrate and benzyl zinc coupling partner. Moreover, benzyl zinc reagent addition to the N-tert-butanesulfinyl imine 3o prepared from isopropylidene-protected glyceraldehyde proceeds in high yield and with exceptional selectivity to provide rapid entry to hydroxyethylamine-based aspartyl protease inhibitors.(Figure Presented)