1268241-48-0

Basic information

• Product Name: (E)-1-(4-methylpiperazin-1-yl)-3-[4-morpholin-4-yl-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-8-yl]propenone
• Synonyms: (E)-1-(4-methylpiperazin-1-yl)-3-[4-morpholin-4-yl-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-8-yl]propenone
• CAS NO: 1268241-48-0
• Molecular Weight: 523.594
• Mol File: 1268241-48-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-1-(4-methylpiperazin-1-yl)-3-[4-morpholin-4-yl-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-8-yl]propenone(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(4-methylpiperazin-1-yl)-3-[4-morpholin-4-yl-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-8-yl]propenone(1268241-48-0)
• EPA Substance Registry System: (E)-1-(4-methylpiperazin-1-yl)-3-[4-morpholin-4-yl-2-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-8-yl]propenone(1268241-48-0)

Safety Data

• Hazardous Substances Data: 1268241-48-0(Hazardous Substances Data)

Upstream product

• 405224-23-9 5-bromo-2-chloropyridine-3-carbonitrile 

Relevant articles and documents

TRICYCLIC HETEROCYCLIC COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE INHIBITORS

Compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein: W is O, N-H, N-(C1-C10 alkyl) or S; each X is independently CH or N; R1 is a 5 to 7-membered saturated or unsaturated, optionally substituted heterocycle containing at least 1 heteroatom selected from N or O; R2 is (LQ)mY; and each R3 is independently H, C1-C10 alkyl, aryl or heteroaryl, are surprisingly found to be inhibitors of PI3K-p110δ, and therefore have utility in therapy.