1268242-45-0Relevant articles and documents
Nickel-catalyzed Negishi cross-coupling reactions of secondary alkylzinc halides and aryl iodides
Joshi-Pangu, Amruta,Ganesh, Madhu,Biscoe, Mark R.
supporting information; experimental part, p. 1218 - 1221 (2011/04/27)
A general Ni-catalyzed process for the cross-coupling of secondary alkylzinc halides and aryl/heteroaryl iodides has been developed. This is the first process to overcome the isomerization and β-hydride elimination problems that are associated with the use of secondary nucleophiles, and that have limited the analogous Pd-catalyzed systems. The impact of salt additives was also investigated. It was found that the presence of LiBF4 dramatically improves both isomeric retention and yield for challenging substrates.(Figure Presented)
