1268246-03-2

Upstream product

• 1219711-47-3 (1-benzenesulfonyl-4-methoxy-4-phenylpiperidin-3-ylidene)acetic acid ethyl ester 
• 762-72-1 allyl-trimethyl-silane 
• 1217795-32-8 C₁₈H₁₉NO₄S 

Downstream Products

• 1313537-86-8 4-allyl-3-benzenesulfonyl-1,2,3,4-tetrahydrobenzo[f]isoquinolin-6-ol 
• 1313537-90-4 2-(2-allyl-1-benzenesulfonyl-4-phenyl-1,2,5,6-tetrahydropyridin-3-yl)ethanol 
• 1313537-97-1 methanesulfonic acid 2-(2-allyl-1-benzenesulfonyl-4-phenyl-1,2,5,6-tetrahydropyridin-3-yl)ethyl ester 
• 1313538-01-0 6-allyl-1-benzenesulfonyl-4-phenyl-5-vinyl-1,2,3,6-tetrahydropyridine 
• 1313538-05-4 1-benzenesulfonyl-4-phenyl-2,3,7,7a-tetrahydro-1H-[1]pyridine 
• 1313538-10-1 (2-allyl-1-benzenesulfonyl-4-phenyl-1,2,5,6-tetrahydropyridin-3-yl)acetaldehyde 
• 1313538-14-5 5,6-diallyl-1-benzenesulfonyl-4-phenyl-1,2,3,6-tetrahydropyridine 
• 1313538-18-9 1-benzenesulfonyl-4-phenyl-1,2,3,5,8,8a-hexahydroquinoline 

Relevant academic research and scientific papers

Synthesis of 1,2,4-trisubstituted-1,2,5,6-tetrahydropyridines

A novel method for the synthesis of 1,2,4-trisubstituted- or 1,2,3,4-tetrasubstituted-1,2,5,6-tetrahydropyridine is presented. The process was carried out by the bromomethoxylation of 4-substituted-1,2,5,6- tetrahydropyridines 1 with N-bromosuccinimide (NBS) in methanol, dehydrobromination with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), and boron trifluoride etherate (BF3-OEt2)-catalyzed cross coupling of the corresponding enamine with trimethylsilyl-based nucleophiles. Homokainoid analogs were also synthesized via the protocol.

Synthesis of tetrahydrobenzoisoquinolinols, tetrahydropyrindines, and hexahydroquinolines from 4-aryltetrahydropyridines

A straightforward synthesis of tetrahydrobenzoisoquinolinols 2, tetrahydropyrindines 3, and hexahydroquinolines 4 from versatile intermediate 6 is reported. Two key transformations were carried out by intramolecular Friedel-Crafts cyclization and ring-clo