1268248-40-3

Upstream product

• 22118-09-8 2-bromoacetyl chloride 
• 1254367-82-2 C₄₀H₄₅ClN₄O₇Si 
• 1254367-46-8 C₂₀H₁₆ClNO₄ 
• 1254367-57-1 (4aS,11aR,12aS,13S)-8-bromo-10-chloro-13-(dimethylamino)-4a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-11a,12,12a,13-tetrahydro-5-hydroxy-3,7-bis(phenylmethoxy)-isoxazolo[5',4':6,7]naphth[2,3-g]-isoquinoline-4,6(4aH,11H)-dione 
• 1254367-59-3 N-[(4aS,11aR,12aS,13S)-10-chloro-13-(dimethylamino)-4a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-11a,12,12a,13-tetrahydro-5-hydroxy-3,7-bis(phenylmethoxy)-isoxazolo[5',4':6,7]naphth[2,3-g]-isoquinolin-8-yl]-carbamic acid 1,1-dimethylethyl ester 
• 1253799-61-9 3-(benzyloxy)-5-chloroisonicotinic acid 
• 1253799-63-1 phenyl 3-(benzyloxy)-5-chloroisonicotinate 
• 1253799-65-3 phenyl 3-(benzyloxy)-5-methylisonicotinate 
• 1254367-41-3 phenyl 5-(benzyloxy)-2-chloro-3-methylisonicotinate 
• 1254367-43-5 C₂₀H₁₇NO₄ 
• 1254367-42-4 phenyl 3-(benzyloxy)-2-bromo-6-chloro-5-methylisonicotinate 
• 100-51-6 benzyl alcohol 

Downstream Products

• 1268248-39-0 N-[(4aS,11aR,12aS,13S)-10-chloro-13-(dimethylamino)-4a-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4,4a,6,11,11a,12,12a,13-octahydro-5-hydroxy-4,6-dioxo-3,7-bis(phenylmethoxy)isoxazolo[50,40:6,7]naphth[2,3-g]isoquinolin-8-yl]-2-[(1,1-dimethylethyl)amino]-acetamide 

Relevant academic research and scientific papers

8-azatetracyclines: Synthesis and evaluation of a novel class of tetracycline antibacterial agents

A novel series of fully synthetic 8-azatetracyclines was prepared and evaluated for antibacterial activity. Compounds were identified that overcome both efflux (tet(K)) and ribosomal protection (tet(M)) tetracycline resistance mechanisms and are active against Gram-positive and Gram-negative organisms. Two compounds were identified that exhibit comparable efficacy to marketed tetracyclines in in vivo models of bacterial infection.