1268263-04-2

Basic information

• Product Name: C₁₉H₂₅ClN₄OS
• CAS NO: 1268263-04-2
• Molecular Weight: 392.953
• Mol File: 1268263-04-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₂₅ClN₄OS(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₂₅ClN₄OS(1268263-04-2)
• EPA Substance Registry System: C₁₉H₂₅ClN₄OS(1268263-04-2)

Safety Data

• Hazardous Substances Data: 1268263-04-2(Hazardous Substances Data)

Upstream product

• 2845-89-8 1-chloro-3-methoxy-benzene 
• 1222997-44-5 2-bromo-5-(4-piperidinopiperidino)-1,3,4-thiadiazole 
• 929626-16-4 2-(3-chloro-5-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 

Relevant articles and documents

Discovery of a series of potent arylthiadiazole H3 antagonists

A series of 2-piperidinopiperidine-5-arylthiadiazoles was synthesized and subjected to a structure-activity relationship (SAR) investigation. The potency of this series was improved to the single digit nanomolar range. The key analogs were shown to be free of P450 issues, and they also maintained good ex vivo activity and brain penetration.