1268273-15-9

Upstream product

• 36315-01-2 4,6-dimethoxy-2-aminopyrimidine 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 1268273-68-2 5-(3-aminophenylthio)-4,6-dimethoxy-N,N-bis(4-methoxybenzyl)pyrimidin-2-amine 
• 1268273-69-3 N-(3-(2-(bis(4-methoxybenzyl)amino)-4,6-dimethoxypyrimidin-5-ylthio)phenyl)propionamide 
• 1268273-70-6 N-(3-(2-amino-4,6-dimethoxypyrimidin-5-ylthio)phenyl)propionamide 
• 1268273-71-7 N-(3-(2-fluoro-4,6-dimethoxypyrimidin-5-ylthio)phenyl)propionamide 
• 1268273-72-8 N-(3-(2-(4-(2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)ethyl)piperazin-1-yl)-4,6-dimethoxypyrimidin-5-ylthio)phenyl)propionamide 
• 1268273-17-1 2-((2-(bis(4-methoxybenzyl)amino)-4,6-dimethoxypyrimidin-5-yl)thio)pyrimidine-4,6-diamine 
• 1268273-18-2 N,N′-(2-((2-(bis(4-methoxybenzyl)amino)-4,6-dimethoxypyrimidin-5-yl)thio)pyrimidine-4,6-diyl)diacetamide 
• 1268273-16-0 5-iodo-4,6-dimethoxy-N,N-bis(4-methoxybenzyl)pyrimidin-2-amine 
• 1568905-44-1 N-(2-((2-(bis(4-methoxybenzyl)amino)-4,6-dimethoxypyrimidin-5-yl)thio)pyrimidin-4-yl)acetamide 
• 1568905-22-5 5-((4-aminopyrimidin-2-yl)thio)-4,6-dimethoxy-N,N-bis(4-methoxybenzyl)pyrimidin-2-amine 

Relevant academic research and scientific papers

Heat shock protein 70 inhibitors. 1. 2,5′-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70

Heat shock protein 70 (Hsp70) is an important emerging cancer target whose inhibition may affect multiple cancer-associated signaling pathways and, moreover, result in significant cancer cell apoptosis. Despite considerable interest from both academia and

HEAT SHOCK PROTEIN BINDING COMPOUNDS, COMPOSITIONS, AND METHODS FOR MAKING AND USING SAME

The present subject matter relates to a compound represented by the general formula (I) or (I') or a pharmacologically acceptable salt thereof; pharmaceutical compositions containing at least one of these compounds; methods of making at least one of these compounds; methods of using at least one of these compounds for treating and/or preventing various cancers and/or proliferation disorders; methods of using at least one of these compounds for monitoring the effectiveness of an anticancer therapy against various cancers. In one embodiment, the subject matter relates to compounds that bind with a level of specificity to heat shock protein 70 (Hsp70). In another embodiment, the subject matter relates to compounds that bind with a level of specificity to inhibit both heat shock protein 70 (Hsp70) and heat shock cognate protein 70 (Hsc70).