1268367-93-6Relevant academic research and scientific papers
Synthesis of biaryl compounds using tandem ruthenium-catalyzed ring-closing metathesis
Yoshida, Kazuhiro,Shida, Hiroaki,Takahashi, Hidetoshi,Yanagisawa, Akira
supporting information; experimental part, p. 344 - 349 (2011/02/27)
Tandem ring-closing enyne metathesis (RCEM)/ring-closing olefin metathesis (RCM) of tetraenynes with Grubbs second-generation catalyst, followed by elimination, was found to be a new and efficient synthetic approach to biaryl compounds. A preliminary asymmetric version of this approach, which used homochiral Ru-alkylidene catalysts, is also presented. A ringing endorsement: Tandem ring-closing enyne metathesis (RCEM)/ring-closing olefin metathesis (RCM) of tetraenynes with the Grubbs second-generation catalyst followed by elimination, was found to be a new and efficient synthetic approach to biaryl compounds (see scheme). A preliminary asymmetric version of this approach is also presented.
