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Nagstatin is a natural product derived from Streptomyces species, characterized by its potent inhibitory effects on the enzyme glucosamine-6-phosphate synthase. This enzyme plays a crucial role in the biosynthesis of peptidoglycan, a vital component of bacterial cell walls. By inhibiting this enzyme, nagstatin effectively disrupts the formation of peptidoglycan, thereby inhibiting bacterial cell wall synthesis. This property has led to the discovery of nagstatin's promising antibacterial activity against a broad spectrum of bacterial strains, positioning it as a potentially valuable compound for the development of new antibiotics. Furthermore, nagstatin has demonstrated anticancer properties through its modulation of the glycosylation process, making it a compound of interest for potential therapeutic applications beyond its antibacterial effects.

126844-81-3

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126844-81-3 Usage

Uses

Used in Pharmaceutical Industry:
Nagstatin is used as an antibacterial agent for its ability to inhibit the enzyme glucosamine-6-phosphate synthase, which is essential for bacterial cell wall synthesis. This inhibition leads to the disruption of peptidoglycan formation, exhibiting promising antibacterial activity against a wide range of bacterial strains.
Used in Oncology Research:
Nagstatin is used as a potential anticancer agent due to its modulation of the glycosylation process. This property makes it a compound of interest for therapeutic applications in cancer treatment, offering a novel approach to target cancer cells and potentially complement existing cancer therapies.

Check Digit Verification of cas no

The CAS Registry Mumber 126844-81-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,6,8,4 and 4 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 126844-81:
(8*1)+(7*2)+(6*6)+(5*8)+(4*4)+(3*4)+(2*8)+(1*1)=143
143 % 10 = 3
So 126844-81-3 is a valid CAS Registry Number.
InChI:InChI=1/C12H17N3O6/c1-5(17)14-9-11(21)10(20)7(4-16)15-6(2-8(18)19)3-13-12(9)15/h3,7,9-11,16,20-21H,2,4H2,1H3,(H,14,17)(H,18,19)

126844-81-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name [8-Acetamido-6,7-dihydroxy-5-(hydroxymethyl)-5,6,7,8-tetrahydroim idazo[1,2-a]pyridin-3-yl]acetic acid

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
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More Details:126844-81-3 SDS

126844-81-3Upstream product

126844-81-3Downstream Products

126844-81-3Related news

Total syntheses of de-branched nagstatin (cas 126844-81-3) and its analogs having glycosidase inhibiting activities07/22/2019

De-branched nagstatin and its analogs have been synthesized from protected L-ribo- and xylofuranoses through the inter- and intra-molecular nucleophilic reactions with the imidazole moieties.detailed

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