126848-98-4

Basic information

• Product Name: N-(2-(1-benzylpiperidin-4-yl)ethyl)isonicotinamide
• Synonyms: N-(2-(1-benzylpiperidin-4-yl)ethyl)isonicotinamide
• CAS NO: 126848-98-4
• Molecular Weight: 323.438
• Mol File: 126848-98-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(2-(1-benzylpiperidin-4-yl)ethyl)isonicotinamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-(1-benzylpiperidin-4-yl)ethyl)isonicotinamide(126848-98-4)
• EPA Substance Registry System: N-(2-(1-benzylpiperidin-4-yl)ethyl)isonicotinamide(126848-98-4)

Safety Data

• Hazardous Substances Data: 126848-98-4(Hazardous Substances Data)

Upstream product

• 14254-57-0 4-(chlorocarbonyl)pyridine 
• 86945-25-7 4-(2-aminoethyl)-1-(phenylmethyl)piperidine 
• 78056-67-4 1-(phenylmethyl)-4-piperidineacetonitrile 
• 55-22-1 pyridine-4-carboxylic acid 

Relevant articles and documents

Synthesis and pharmacological evaluation of donepezil-based agents as new cholinesterase/monoamine oxidase inhibitors for the potential application against Alzheimer’s disease

In a continuing effort to develop multitargeted compounds as potential treatment agents against Alzheimer's disease (AD), a series of donepezil-like compounds were designed, synthesized and evaluated. In vitro studies showed that most of the designed compounds displayed potent inhibitory activities toward AChE, BuChE, MAO-B and MAO-A. Among them, w18 was a promising agent with balanced activities, which exhibited a moderate cholinesterase inhibition (IC50, 0.220 μM for eeAChE; 1.23 μM for eqBuChE; 0.454 μM for hAChE) and an acceptable inhibitory activity against monoamine oxidases (IC50, 3.14 μM for MAO-B; 13.4 μM for MAO-A). Moreover, w18 could also be a metal-chelator, and able to cross the blood–brain barrier with low cell toxicity on PC12 cells. Taken together, these results suggested that w18 might be a promising multitargeted compound for AD treatment.