1268490-93-2Relevant academic research and scientific papers
Synthesis of functionalized chromene and spirochromenes using L-proline-melamine as highly efficient and recyclable homogeneous catalyst at room temperature
Nagaraju, Sakkani,Paplal, Banoth,Sathish, Kota,Giri, Santanab,Kashinath, Dhurke
, p. 4200 - 4204 (2017)
An efficient and recyclable homogeneous catalyst is developed using commercially cheap L-proline and melamine for the synthesis of chromenes and spirochromenes (spirooxindoles) via multicomponent reactions at room temperature. Systematic studies were conducted in order to achieve desired reactivity and recyclability of the catalyst using various α-amino acids and aromatic amines as donor-acceptor pairs. Among the screened combinations, L-proline and melamine (3:1 ratio; 3 mol% on total weight) was found to be best catalyst to give the desired products with excellent yields (up to 99%) in very short times (1–15 min) at room temperature in DMSO as solvent. The catalyst was recovered by adding EtOAc and reused up to 5 cycles without losing the catalytic activity.
Simple and efficient method for three-component synthesis of spirooxindoles in aqueous and solvent-free media
Mobinikhaledi, Akbar,Foroughifar, Naser,Fard, Mohammad Ali Bodaghi
experimental part, p. 441 - 450 (2011/04/15)
A clean, simple, one-pot, three-component synthesis of some important spirooxindole derivatives in the presence of tetrabutylammonium bromide (TBAB) was carried out under green and environmentally benign conditions.
