1268527-46-3 Usage
Uses
Used in Pharmaceutical and Medicinal Research:
(E)-N-(2-(5-(benzo[d]thiazol-2-yl)-1-phenyl-1H-benzo[d]imidazol-2-yl)vinyl)-N-methylaniline is used as a compound in pharmaceutical and medicinal research for its potential biological activity and therapeutic properties. Its complex structure and functional groups make it a promising candidate for the development of new drugs and therapies.
Used in Chemical Industry:
In the chemical industry, (E)-N-(2-(5-(benzo[d]thiazol-2-yl)-1-phenyl-1H-benzo[d]imidazol-2-yl)vinyl)-N-methylaniline is used as a starting material or intermediate for the synthesis of various organic materials, including dyes and pigments. Its unique structure and functional groups allow for the creation of a wide range of products with different properties and applications.
Used in Materials Science:
(E)-N-(2-(5-(benzo[d]thiazol-2-yl)-1-phenyl-1H-benzo[d]imidazol-2-yl)vinyl)-N-methylaniline is also used in materials science for the development of new materials with specific properties. Its complex structure and functional groups can be exploited to create materials with unique characteristics, such as improved conductivity, enhanced stability, or novel optical properties.
Used in Research and Development:
(E)-N-(2-(5-(benzo[d]thiazol-2-yl)-1-phenyl-1H-benzo[d]imidazol-2-yl)vinyl)-N-methylaniline is used as a subject for research and development in various scientific fields, including chemistry, biology, and materials science. Its complex nature and potential applications make it an interesting target for further exploration and innovation.
Check Digit Verification of cas no
The CAS Registry Mumber 1268527-46-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,8,5,2 and 7 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1268527-46:
(9*1)+(8*2)+(7*6)+(6*8)+(5*5)+(4*2)+(3*7)+(2*4)+(1*6)=183
183 % 10 = 3
So 1268527-46-3 is a valid CAS Registry Number.
1268527-46-3Relevant academic research and scientific papers
Synthesis and biological evaluation of analogues of AKT (protein kinase B) inhibitor-IV
Sun, Qi,Wu, Runzhi,Cai, Sutang,Lin, Yuan,Sellers, Llewlyn,Sakamoto, Kaori,He, Biao,Peterson, Blake R.
, p. 1126 - 1139 (2011/04/25)
Inhibitors of the PI3-kinase/AKT (protein kinase B) pathway are under investigation as anticancer and antiviral agents. The benzimidazole derivative AKT inhibitor-IV (ChemBridge 5233705) affects this pathway and exhibits potent anticancer and antiviral activity. To probe its biological activity, we synthesized AKT inhibitor-IV and 21 analogues using a novel six-step route based on ZrCl4-catalyzed cyclization of 1,2-arylenediamines with α,β-unsaturated aldehydes. We examined effects on viability of HeLa carcinoma cells, viability of normal human cells (NHBE), replication of recombinant parainfluenza virus 5 (PIV5) in HeLa cells, and replication of the intracellular bacterium Mycobacterium fortuitum in HeLa cells. Replacement of the benzimidazole N-ethyl substitutent of AKT inhibitor-IV with N-hexyl and N-dodecyl groups enhanced antiviral activity and cytotoxicity against the cancer cell line, but these compounds showed substantially lower toxicity (from 6-fold to >20-fold) against NHBE cells and no effect on M. fortuitum, suggesting inhibition of one or more host protein(s) required for proliferation of cancer cells and PIV5. The key structural elements identified here may facilitate identification of targets of this highly biologically active scaffold.
