1268617-86-2Relevant academic research and scientific papers
Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGFβ) Production in Regulatory T-Cells
Powell, Jonathan,Mota, Filipa,Steadman, David,Soudy, Christelle,Miyauchi, Jeremy T.,Crosby, Stuart,Jarvis, Ashley,Reisinger, Tifelle,Winfield, Natalie,Evans, Graham,Finniear, Aled,Yelland, Tamas,Chou, Yi-Tai,Chan, A.W. Edith,O'Leary, Andrew,Cheng, Lili,Liu, Dan,Fotinou, Constantina,Milagre, Carla,Martin, John F.,Jia, Haiyan,Frankel, Paul,Djordjevic, Snezana,Tsirka, Stella E.,Zachary, Ian C,Selwood, David L.
, p. 4135 - 4154 (2018/05/23)
We report the design, synthesis, and biological evaluation of some potent small-molecule neuropilin-1 (NRP1) antagonists. NRP1 is implicated in the immune response to tumors, particularly in Treg cell fragility, required for PD1 checkpoint blockade. The d
NP-1 ANTAGONISTS AND THEIR THERAPEUTIC USE
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Page/Page column 19; 23; 27, (2011/04/14)
Compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein: W is arylene, heteroarylene or formula (a) each L is independently alkylene, alkenylene, alkynylene, a direct bond, arylene, cycloalkylene, alkylene-arylene, alkylene-C=O or
