1268625-01-9Relevant academic research and scientific papers
Probing the role of the mycosamine C2′-OH on the activity of amphotericin B
Croatt, Mitchell P.,Carreira, Erick M.
, p. 1390 - 1393 (2011/05/08)
A synthetic route to a mycosamine donor was designed and provided access to a set of AmB derivatives targeted to probe the effect of the C2′-OH. It was determined that the configuration of the C2′-position is inconsequential but that O-methylation of this alcohol was deleterious to its mode of action. Additionally, the analog incorporating a mycosamine derivative from the enantiomeric series was devoid of activity.
