1268631-75-9Relevant academic research and scientific papers
Chemical synthesis of coelenterazine and its analogs: New route by four segment-couplings
Chou, Chun-Ming,Tung, Yu-Wen,Lin, Meng-I,Chan, Diana,Phakhodee, Wong,Isobe, Minoru
, p. 1323 - 1339 (2013/08/15)
A novel and improved synthetic route includes four segment-couplings toward coelenterazine and its analogs as luminescent molecules. Regio- and chemo-selective cross coupling reactions using palladium catalysts with 5-iodo-3-bromo-2-aminopyrazine have enabled providing various aminopyrazine derivatives having different substituents. The improved synthesis of coelenterazine and its analogs employed advanced condensation with the aminopyrazines using various keto-acetal segments, which resulted in much higher yields to give the final imidazopyrazinone heterocycles than the previous method using keto-aldehydes.
Suzuki-Miyaura coupling for general synthesis of dehydrocoelenterazine applicable for 6-position analogs directing toward bioluminescence studies
Phakhodee, Wong,Toyoda, Mitsuko,Chou, Chun-Ming,Khunnawutmanotham, Nisachon,Isobe, Minoru
experimental part, p. 1150 - 1157 (2011/03/21)
Synthesis of coelenterazine analogs is in recent demand to supply more luminescent compounds with reasonable stability as substrate for the photoprotein manipulated in a living cells or particular organelle. There are limited methods for the synthesis of
