1268686-82-3Relevant academic research and scientific papers
Kinetic Resolution and Dynamic Kinetic Resolution of γ-Aryl-Substituted Butenolides via Copper-Catalyzed 1,4-Hydroboration
Lee, Soyeon,Ryu, Do Hyun,Yun, Jaesook
, p. 2377 - 2381 (2021)
Kinetic resolution (KR) and dynamic kinetic resolution (DKR) of γ-aryl and heteroaryl-substituted butenolides via CuH-catalyzed 1,4-hydroboration using pinacolborane is reported. With a copper-Ph-BPE catalyst, selectivity factors were extremely high (s=>400) with regard to the kinetic resolution of β-methyl-γ-phenyl butenolide; DKR was possible in the presence of an amine base (DBU), which facilitated racemization of the starting unsaturated lactones. The reaction provided easy access to highly enantioenriched γ-butyrolactones (>99% ee) containing β,γ-substituents. (Figure presented.).
Base-mediated tandem reaction consisting of an acyl shift strategy leading to 4,5-disubstiuted furan-2(5H)-ones
Lei, Yong,Wang, Zhi-Qiang,Xie, Ye-Xiang,Yu, Shang-Ci,Tang, Bo-Xiao,Li, Jin-Heng
supporting information; experimental part, p. 31 - 35 (2011/03/20)
The first example of the synthesis of 4,5-disubstiuted furan-2(5H)-ones by base-mediated tandem acyl shift/cyclization/decarbonylation reactions of aroylmethyl 2-alkynoates has been developed. This new and inexpensive tandem route allows both a C-O bond a
